Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia
نویسندگان
چکیده
منابع مشابه
Brilliant blue FCF as an alternative dye for saphenous vein graft marking: effect on conduit function.
IMPORTANCE Surgical skin markers are used off-label to mark human saphenous veins (HSVs) to maintain orientation before implantation as aortocoronary or peripheral arterial bypass grafts. These surgical skin markers impair functional responses of the HSV tissue. OBJECTIVES To investigate the effect of brilliant blue dye 1 (brilliant blue FCF [for food coloring]; hereinafter, FCF) as a nontoxi...
متن کاملSiO2–TiO2 xerogels for tailoring the release of brilliant blue FCF
Xerogels consisting of SiO2 and TiO2 were explored for controlled release of brilliant blue FCF (BBF). Both SiO2 and SiO2–TiO2 xerogels were prepared by way of sol–gel processing, and the BBF release behavior was compared. SiO2–TiO2 xerogels with varying TiO2 content were also studied and the BBF release behavior was determined for each SiO2–TiO2 xerogel. It was found that the release of BBF fr...
متن کاملReduction of vein graft intimal hyperplasia by ex vivo treatment with desferrioxamine manganese.
Reversed vein grafting exposes the venous tissue to a period of ischemia, reperfusion and subsequent free radical generation which may contribute to endothelial injury and/or damage, smooth muscle cell proliferation and the later development of intimal hyperplasia. The effects of ex vivo treatment with desferrioxamine Mn+3 (DFMn), a cell-permeable free radical scavenger, on the development of i...
متن کاملPhotochemical Tissue Passivation Reduces Vein Graft Intimal Hyperplasia in a Swine Model of Arteriovenous Bypass Grafting
BACKGROUND Bypass grafting remains the standard of care for coronary artery disease and severe lower extremity ischemia. Efficacy is limited by poor long-term venous graft patency secondary to intimal hyperplasia (IH) caused by venous injury upon exposure to arterial pressure. We investigate whether photochemical tissue passivation (PTP) treatment of vein grafts modulates smooth muscle cell (SM...
متن کاملFK778 attenuates cytomegalovirus-enhanced vein graft intimal hyperplasia in a rat model.
BACKGROUND Venous grafts are commonly used to treat drug-resistant coronary artery disease, although long-term functionality is limited because of proliferation and migration of smooth muscle cells (SMC). As proliferating SMC are particularly susceptible for the stimulating effects of cytomegalovirus (CMV), we hypothesized that CMV infection may enhance cell proliferation and graft failure. Fur...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2016
ISSN: 0741-5214
DOI: 10.1016/j.jvs.2015.02.028